Oxygen saturation and retinopathy of prematurity

Oxygen free radicals and retinopathy of prematurity.

High or low oxygen saturation and severe retinopathy of prematurity: a meta-analysis.

CONTEXT Low oxygen saturation appears to decrease the risk of severe retinopathy of prematurity (ROP) in preterm newborns when administered during the first few weeks after birth. High oxygen saturation seems to reduce the risk at later postmenstrual ages (PMAs). However, previous clinical studies are not conclusive individually. OBJECTIVE To perform a systematic review and meta-analysis to r...

Retinopathy of prematurity: oxygen dogma challenged.

Lower oxygen saturation alarm limits decrease the severity of retinopathy of prematurity.

PURPOSE To determine whether lowering oxygen saturation alarm limits for infants at risk for retinopathy of prematurity (ROP) reduces its incidence and/or severity. METHODS Oximetry alarm limits were lowered to 85% and 93% for all infants with a birth weight 1250 g or less and/or gestational age 28 weeks or less, and maintained until 32 weeks' postmenstrual age or until oxygen saturations wer...

[Retinopathy of prematurity and oxygen therapy: a changing relationship].

INTRODUCTION The use of oxygen was implemented in neonatal practice in the absence of any randomized studies. The dose was (and still is in some places) not measured well. Additionally, the newborn’s oxygenation levels were not measured routinely until Arterial Blood Gases (ABG’s), capillary samples, transcutaneous PO2 (TcPO2) and, more recently, monitoring of oxygen saturation by pulse oximetr...